One of the best features of NextBigNiche is its Search Volume Change tracker, which helps spot trends early. Over the past three months, we've seen a surge in demand for certain supplements—many of which cater to biohackers, fitness enthusiasts, and wellness-conscious consumers.
Let’s dive into the top trending supplement keywords and analyze the market insights behind their rise.

1. Betaine (+62% Search Volume Increase)
What is it?
Betaine is a naturally occurring compound that supports digestion, heart health, and muscle performance. It is commonly used in sports nutrition for improving endurance and reducing fatigue.
Market Overview:
- 30-Day Revenue: $1M
- Average Revenue per Seller: $24K
- Median Reviews: 214
Top Performing Brand:
- Pure Encapsulations
- 30-Day Revenue: $100K
- Unit Sales: 2K

2. L-Carnitine (+101% Search Volume Increase)
What is it?
L-Carnitine is a popular supplement for weight loss and energy production. It helps the body convert fat into energy and is often used by athletes and individuals following ketogenic diets.
Market Overview:
- Total Revenue: $2.7M
- Average Revenue per Seller: $58K
- Median Reviews: 737
Top Performing Brand:
- PROSUPPS
- 30-Day Revenue: $284K
- Unit Sales: 10K

3. BPC-157 Peptide (+122% Search Volume Increase)
What is it?
BPC-157 is a synthetic peptide known for its potential in healing injuries, improving gut health, and reducing inflammation. It’s gaining traction in the biohacking community for its regenerative properties.
Market Overview:
- 30-Day Revenue: $1M
- Average Revenue per Seller: $19K
- Median Reviews: 171
Top Performing Brand:
- Unnamed Leading Brand
- 30-Day Revenue: $200K
- Unit Sales: 3K

4. Lycopene Supplements for Men (+147% Search Volume Increase)
What is it?
Lycopene is an antioxidant found in tomatoes, known for supporting heart health and prostate function in men.
Market Overview:
- 30-Day Revenue: $1M
- Average Revenue per Seller: $20K
- Median Reviews: 121
Top Performing Brand:
- Life Extension Store
- 30-Day Revenue: $20K
- Unit Sales: 1K

5. Resveratrol NAD (+183% Search Volume Increase)
What is it?
Resveratrol is a compound linked to anti-aging and longevity. When combined with NAD (Nicotinamide Adenine Dinucleotide), it enhances cellular energy production and DNA repair.
Market Overview:
- 30-Day Revenue: $7M
- Average Revenue per Seller: $150K
- Median Reviews: 48
Top Performing Brand:
- Cata-Kor
- 30-Day Revenue: $1.8M
- Unit Sales: 40K

6. Cortisol Supplements for Women (+187% Search Volume Increase)
What is it?
These supplements help regulate stress hormones, improve mood, and support weight management.
Market Overview:
- 30-Day Revenue: $3M
- Average Revenue per Seller: $77K
- Median Reviews: 128
Top Performing Brand:
- Integrative Therapeutics
- 30-Day Revenue: $1.4M
- Unit Sales: 37K

7. GLP-1 Supplements for Weight Loss in Women (+191% Search Volume Increase)
What is it?
GLP-1 (Glucagon-Like Peptide-1) supplements are rising in popularity for appetite control and metabolic health, mimicking the effects of prescription weight-loss medications.
Market Overview:
- 30-Day Revenue: $4.5M
- Average Revenue per Seller: $95K
- Median Reviews: 7
Top Performing Brand:
- Triquetra Health
- 30-Day Revenue: $300K
- Unit Sales: 7K

8. Hawthorn Berry Supplement (+229% Search Volume Increase)
What is it?
Hawthorn berry is widely used for heart health, blood pressure regulation, and improved circulation.
Market Overview:
- 30-Day Revenue: $1.3M
- Average Revenue per Seller: $28K
- Median Reviews: 273
Top Performing Brand:
- Herbal Roots
- 30-Day Revenue: $67K
- Unit Sales: 3K

2. SP-6 Probiotics Whitening Toothpaste (+278% Search Volume Increase)
What is it?
A unique blend of probiotics and whitening agents that promote oral health while brightening teeth.
Market Overview:
- 30-Day Revenue: $5M
- Average Revenue per Seller: $100K
- Median Reviews: 14
Top Performing Brand:
- SITUDAC
- 30-Day Revenue: $220K
- Unit Sales: 14K

10. Guava Pulp Extract & Spirulina Algae (+376% Search Volume Increase)
What is it?
Guava pulp extract is packed with antioxidants and vitamins, while spirulina algae is a nutrient-dense superfood known for its immune-boosting and detoxifying properties.
Market Overview:
- 30-Day Revenue: $3M
- Average Revenue per Seller: $55K
- Median Reviews: 14
Top Performing Brand:
- Florida Herbal Pharmacy
- 30-Day Revenue: $25K
- Unit Sales: 1K

Final Thoughts
Tracking search volume trends helps identify emerging niches early. Whether it’s biohacking, weight loss, or longevity supplements, these products show strong growth potential.
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