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Top Trending Supplement Keywords & Market Insights – NextBigNiche

Updated on: March 28, 2025

One of the best features of NextBigNiche is its Search Volume Change tracker, which helps spot trends early. Over the past three months, we've seen a surge in demand for certain supplements—many of which cater to biohackers, fitness enthusiasts, and wellness-conscious consumers.

Let’s dive into the top trending supplement keywords and analyze the market insights behind their rise.

NextBigNiche

1. Betaine (+62% Search Volume Increase)

What is it?
Betaine is a naturally occurring compound that supports digestion, heart health, and muscle performance. It is commonly used in sports nutrition for improving endurance and reducing fatigue.

Market Overview:

  • 30-Day Revenue: $1M
  • Average Revenue per Seller: $24K
  • Median Reviews: 214

Top Performing Brand:

  • Pure Encapsulations
    • 30-Day Revenue: $100K
    • Unit Sales: 2K
Betaine

2. L-Carnitine (+101% Search Volume Increase)

What is it?
L-Carnitine is a popular supplement for weight loss and energy production. It helps the body convert fat into energy and is often used by athletes and individuals following ketogenic diets.

Market Overview:

  • Total Revenue: $2.7M
  • Average Revenue per Seller: $58K
  • Median Reviews: 737

Top Performing Brand:

  • PROSUPPS
    • 30-Day Revenue: $284K
    • Unit Sales: 10K
L-Carnitine

3. BPC-157 Peptide (+122% Search Volume Increase)

What is it?
BPC-157 is a synthetic peptide known for its potential in healing injuries, improving gut health, and reducing inflammation. It’s gaining traction in the biohacking community for its regenerative properties.

Market Overview:

  • 30-Day Revenue: $1M
  • Average Revenue per Seller: $19K
  • Median Reviews: 171

Top Performing Brand:

  • Unnamed Leading Brand
    • 30-Day Revenue: $200K
    • Unit Sales: 3K
BPC-157 Peptide

4. Lycopene Supplements for Men (+147% Search Volume Increase)

What is it?
Lycopene is an antioxidant found in tomatoes, known for supporting heart health and prostate function in men.

Market Overview:

  • 30-Day Revenue: $1M
  • Average Revenue per Seller: $20K
  • Median Reviews: 121

Top Performing Brand:

  • Life Extension Store
    • 30-Day Revenue: $20K
    • Unit Sales: 1K
Lycopene Supplements for Men

5. Resveratrol NAD (+183% Search Volume Increase)

What is it?
Resveratrol is a compound linked to anti-aging and longevity. When combined with NAD (Nicotinamide Adenine Dinucleotide), it enhances cellular energy production and DNA repair.

Market Overview:

  • 30-Day Revenue: $7M
  • Average Revenue per Seller: $150K
  • Median Reviews: 48

Top Performing Brand:

  • Cata-Kor
    • 30-Day Revenue: $1.8M
    • Unit Sales: 40K
Resveratrol NAD

6. Cortisol Supplements for Women (+187% Search Volume Increase)

What is it?
These supplements help regulate stress hormones, improve mood, and support weight management.

Market Overview:

  • 30-Day Revenue: $3M
  • Average Revenue per Seller: $77K
  • Median Reviews: 128

Top Performing Brand:

  • Integrative Therapeutics
    • 30-Day Revenue: $1.4M
    • Unit Sales: 37K
Cortisol Supplements for Women

7. GLP-1 Supplements for Weight Loss in Women (+191% Search Volume Increase)

What is it?
GLP-1 (Glucagon-Like Peptide-1) supplements are rising in popularity for appetite control and metabolic health, mimicking the effects of prescription weight-loss medications.

Market Overview:

  • 30-Day Revenue: $4.5M
  • Average Revenue per Seller: $95K
  • Median Reviews: 7

Top Performing Brand:

  • Triquetra Health
    • 30-Day Revenue: $300K
    • Unit Sales: 7K
Screenshot 2025-03-28 at 15.10.02.png

8. Hawthorn Berry Supplement (+229% Search Volume Increase)

What is it?
Hawthorn berry is widely used for heart health, blood pressure regulation, and improved circulation.

Market Overview:

  • 30-Day Revenue: $1.3M
  • Average Revenue per Seller: $28K
  • Median Reviews: 273

Top Performing Brand:

  • Herbal Roots
    • 30-Day Revenue: $67K
    • Unit Sales: 3K
Screenshot 2025-03-28 at 15.10.46.png

2. SP-6 Probiotics Whitening Toothpaste (+278% Search Volume Increase)

What is it?
A unique blend of probiotics and whitening agents that promote oral health while brightening teeth.

Market Overview:

  • 30-Day Revenue: $5M
  • Average Revenue per Seller: $100K
  • Median Reviews: 14

Top Performing Brand:

  • SITUDAC
    • 30-Day Revenue: $220K
    • Unit Sales: 14K
Screenshot 2025-03-28 at 15.11.31.png

10. Guava Pulp Extract & Spirulina Algae (+376% Search Volume Increase)

What is it?
Guava pulp extract is packed with antioxidants and vitamins, while spirulina algae is a nutrient-dense superfood known for its immune-boosting and detoxifying properties.

Market Overview:

  • 30-Day Revenue: $3M
  • Average Revenue per Seller: $55K
  • Median Reviews: 14

Top Performing Brand:

  • Florida Herbal Pharmacy
    • 30-Day Revenue: $25K
    • Unit Sales: 1K
Guava Pulp Extract & Spirulina Algae

Final Thoughts

Tracking search volume trends helps identify emerging niches early. Whether it’s biohacking, weight loss, or longevity supplements, these products show strong growth potential.

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